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Gene : CISH Homo sapiens

Name  ? cytokine inducible SH2 containing protein Cytological Location  3p21.2
Brief Description  cytokine inducible SH2 containing protein
Description  The protein encoded by this gene contains a SH2 domain and a SOCS box domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by IL2, IL3, GM-CSF and EPO in hematopoietic cells. Proteasome-mediated degradation of this protein has been shown to be involved in the inactivation of the erythropoietin receptor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
  • synonyms:
  • NM_145071,
  • CIS-1,
  • G18,
  • CIS,
  • SOCS,
  • cytokine inducible SH2-containing protein,
  • CIS-1,
  • OTTHUMG00000156853,
  • CISH,
  • Z77852,
  • CIS,
  • SOCS,
  • uc003dax.4,
  • G18,
  • BACTS2,
  • HGNC:1984
  • identifiers:
  • 1154,
  • ENSG00000114737,
  • CISH

Genome feature

Region: gene ? Length: 5321  
Location: 3:50606454-50611774 reverse strand Cyto location: 3p21.2


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Gene -> HPO annotation (Human Phenotype Ontology)

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Proteins

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SNPs

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Disease

3 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

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Expression

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Other

58 SN Ps

5 Cross References

18 Data Sets

5 Homologues

0 Located Features

97 Rna Seq Results