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Gene : AP2M1 Homo sapiens

Name  ? adaptor related protein complex 2 subunit mu 1 Cytological Location  3q27.1
Brief Description  adaptor related protein complex 2 subunit mu 1
Description  This gene encodes a subunit of the heterotetrameric coat assembly protein complex 2 (AP2), which belongs to the adaptor complexes medium subunits family. The encoded protein is required for the activity of a vacuolar ATPase, which is responsible for proton pumping occurring in the acidification of endosomes and lysosomes. The encoded protein may also play an important role in regulating the intracellular trafficking and function of CTLA-4 protein. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2015]
  • synonyms:
  • NM_004068,
  • clathrin adaptor complex AP2, mu subunit,
  • AP50,
  • plasma membrane adaptor AP-2 50kDA protein,
  • MRD60,
  • U36188,
  • CLAPM1,
  • adaptor related protein complex 2 mu 1 subunit,
  • clathrin-associated/assembly/adaptor protein, medium 1,
  • HGNC:564,
  • HA2 50 kDA subunit,
  • mu2,
  • AP-2 mu 2 chain,
  • mu2,
  • uc062qrr.1,
  • clathrin coat adaptor protein AP50,
  • AP2M1,
  • OTTHUMG00000156822,
  • CLAPM1,
  • AP50,
  • clathrin assembly protein complex 2 medium chain
  • identifiers:
  • 1173,
  • ENSG00000161203,
  • AP2M1

Genome feature

Region: gene ? Length: 9237  
Location: 3:184174855-184184091 Cyto location: 3q27.1

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50 Pathways

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene --> Proteins.


Gene Report --> GWAS hit


1 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene --> Physical and Genetic Interactions


Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.



50 Pathways

725 SNPs

5 Cross References

18 Data Sets

8 Homologues

0 Located Features

97 Rna Seq Results