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Gene : CLPS Homo sapiens

Name  ? colipase Cytological Location  6p21.31
Brief Description  colipase
Description  The protein encoded by this gene is a cofactor needed by pancreatic lipase for efficient dietary lipid hydrolysis. It binds to the C-terminal, non-catalytic domain of lipase, thereby stabilizing an active conformation and considerably increasing the overall hydrophobic binding site. The gene product allows lipase to anchor noncovalently to the surface of lipid micelles, counteracting the destabilizing influence of intestinal bile salts. This cofactor is only expressed in pancreatic acinar cells, suggesting regulation of expression by tissue-specific elements. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
  • synonyms:
  • NM_001832,
  • OTTHUMG00000014578,
  • uc003ole.3,
  • colipase, pancreatic,
  • CLPS,
  • pancreatic colipase,
  • HGNC:2085
  • identifiers:
  • 1208,
  • ENSG00000137392,
  • CLPS

Genome feature

Region: gene ? Length: 2342  
Location: 6:35794982-35797323 reverse strand Cyto location: 6p21.31


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Function

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Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Genomics

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Gene --> GO terms.

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Proteins

Gene --> Proteins.

SNPs

Gene Report --> GWAS hit

Disease

0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Homology

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Interactions

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Expression

Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

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Other

365 SN Ps

5 Cross References

16 Data Sets

2 Homologues

0 Located Features

97 Rna Seq Results