Name
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alkB homolog 2, alpha-ketoglutarate dependent dioxygenase | Cytological Location | 12q24.11 |
Brief Description | alkB homolog 2, alpha-ketoglutarate dependent dioxygenase |
Description | The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA. ALKBH2 and ALKBH3 (MIM 610603) are E. coli AlkB homologs that catalyze the removal of 1-methyladenine and 3-methylcytosine (Duncan et al., 2002 [PubMed 12486230]).[supplied by OMIM, Mar 2008] |