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Gene : CCR5 Homo sapiens

Name  ? C-C motif chemokine receptor 5 (gene/pseudogene) Cytological Location  3p21.31
Brief Description  C-C motif chemokine receptor 5 (gene/pseudogene)
Description  This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. An allelic polymorphism in this gene results in both functional and non-functional alleles; the reference genome represents the functional allele. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2015]
  • synonyms:
  • chemokine (C-C motif) receptor 5 (gene/pseudogene),
  • HGNC:1606,
  • CKR5,
  • OTTHUMG00000133481,
  • uc062izs.1,
  • CD195,
  • CCCKR5,
  • CKR-5,
  • CKR-5,
  • CCR-5,
  • CD195,
  • CCR5,
  • NM_000579,
  • CMKBR5,
  • IDDM22,
  • CKR5,
  • CMKBR5,
  • CC-CKR-5,
  • chemokine (C-C motif) receptor 5,
  • IDDM22,
  • CC-CKR-5
  • identifiers:
  • 1234,
  • ENSG00000160791,
  • CCR5

Genome feature

Region: gene ? Length: 6065  
Location: 3:46370142-46376206 Cyto location: 3p21.31

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3 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

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Gene -> HPO annotation (Human Phenotype Ontology)

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Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.



586 SN Ps

5 Cross References

17 Data Sets

8 Homologues

0 Located Features

97 Rna Seq Results