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Gene : ABCC2 Homo sapiens

Name  ? ATP binding cassette subfamily C member 2 Cytological Location  10q24.2
Brief Description  ATP binding cassette subfamily C member 2
Description  The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia. [provided by RefSeq, Jul 2008]
  • synonyms:
  • HGNC:53,
  • CMOAT,
  • U63970,
  • MRP2,
  • CMOAT,
  • OTTHUMG00000018895,
  • MRP2,
  • DJS,
  • ATP-binding cassette, sub-family C (CFTR/MRP), member 2,
  • canalicular multispecific organic anion transporter 1,
  • ABCC2,
  • NM_000392,
  • ABC30,
  • cMRP,
  • cMRP,
  • DJS,
  • uc001kqf.3
  • identifiers:
  • 1244,
  • ENSG00000023839,
  • ABCC2

Genome feature

Region: gene ? Length: 71140  
Location: 10:99782602-99853741 Cyto location: 10q24.2

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Gene -> HPO annotation (Human Phenotype Ontology)

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1 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene(s) --> Significant SNPs (GTex data)

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Gene --> GO terms.



3756 SN Ps

5 Cross References

20 Data Sets

15 Homologues

0 Located Features

97 Rna Seq Results