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Gene : COX4I1 Homo sapiens

Name  ? cytochrome c oxidase subunit 4I1 Cytological Location  16q24.1
Brief Description  cytochrome c oxidase subunit 4I1
Description  Cytochrome c oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial- and nuclear-encoded subunits. The mitochondrially-encoded subunits perform the electron transfer and proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex. This gene encodes the nuclear-encoded subunit IV isoform 1 of the human mitochondrial respiratory chain enzyme. It is located at the 3' of the NOC4 (neighbor of COX4) gene in a head-to-head orientation, and shares a promoter with it. Pseudogenes related to this gene are located on chromosomes 13 and 14. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]
  • synonyms:
  • OTTHUMG00000137649,
  • NM_001861,
  • COX4I1,
  • COXIV,
  • COX4,
  • uc059yaj.1,
  • AF005889,
  • cytochrome c oxidase subunit IV isoform 1,
  • COXIV-1,
  • COX4,
  • MC4DN16,
  • COX4-1,
  • COX4-1,
  • COX IV-1,
  • cytochrome c oxidase subunit IV,
  • HGNC:2265
  • identifiers:
  • 1327,
  • ENSG00000131143,
  • COX4I1

Genome feature

Region: gene ? Length: 7374  
Location: 16:85799695-85807068 Cyto location: 16q24.1

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Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene --> Chromosomal location.

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Gene --> Proteins.


Gene Report --> GWAS hit


1 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene --> Physical and Genetic Interactions


Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.



321 SNPs

5 Cross References

19 Data Sets

11 Homologues

0 Located Features

97 Rna Seq Results