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Gene : COX11 Homo sapiens

Name  ? cytochrome c oxidase copper chaperone COX11 Cytological Location  17q22
Brief Description  cytochrome c oxidase copper chaperone COX11
Description  Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be a heme A biosynthetic enzyme involved in COX formation, according to the yeast mutant studies. However, the studies in Rhodobacter sphaeroides suggest that this gene is not required for heme A biosynthesis, but required for stable formation of the Cu(B) and magnesium centers of COX. This human protein is predicted to contain a transmembrane domain localized in the mitochondrial inner membrane. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene has been found on chromosome 6. [provided by RefSeq, Jun 2009]
  • synonyms:
  • cytochrome c oxidase subunit 11,
  • OTTHUMG00000177838,
  • AF044321,
  • cytochrome c oxidase assembly homolog 11 (yeast),
  • COX11,
  • COX11 (yeast) homolog, cytochrome c oxidase assembly protein,
  • cytochrome c oxidase assembly protein COX11,
  • COX11P,
  • COX11P,
  • HGNC:2261,
  • uc010wng.2,
  • COX11, cytochrome c oxidase copper chaperone,
  • NM_004375
  • identifiers:
  • 1353,
  • ENSG00000166260,
  • COX11

Genome feature

Region: gene ? Length: 16888  
Location: 17:54951898-54968785 reverse strand Cyto location: 17q22

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0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

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Gene -> HPO annotation (Human Phenotype Ontology)

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3740 SNPs

5 Cross References

15 Data Sets

6 Homologues

0 Located Features

97 Rna Seq Results