help  | about  | cite  | software

Gene : CPE Homo sapiens

Name  ? carboxypeptidase E Cytological Location  4q32.3
Brief Description  carboxypeptidase E
Description  This gene encodes a member of the M14 family of metallocarboxypeptidases. The encoded preproprotein is proteolytically processed to generate the mature peptidase. This peripheral membrane protein cleaves C-terminal amino acid residues and is involved in the biosynthesis of peptide hormones and neurotransmitters, including insulin. This protein may also function independently of its peptidase activity, as a neurotrophic factor that promotes neuronal survival, and as a sorting receptor that binds to regulated secretory pathway proteins, including prohormones. Mutations in this gene are implicated in type 2 diabetes. [provided by RefSeq, Nov 2015]
  • synonyms:
  • CPH,
  • cobalt-stimulated chromaffin granule carboxypeptidase,
  • uc003irg.5,
  • CPE,
  • NM_001873,
  • carboxypeptidase H,
  • enkephalin convertase,
  • OTTHUMG00000150252,
  • HGNC:2303,
  • X51405,
  • insulin granule-associated carboxypeptidase
  • identifiers:
  • 1363,
  • ENSG00000109472,
  • CPE

Genome feature

Region: gene ? Length: 119540  
Location: 4:165379008-165498547 Cyto location: 4q32.3

Uni Prot Comments Displayer

Protein Atlas Displayer

Gene Expression Atlas Tissues Displayer

Gene Expression Atlas Diseases Displayer

Publication Counts Displayer

Curated Proteins Displayer


Gene Ontology Displayer

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


J Browse Displayer

Gene Structure Displayer

Overlapping Features Displayer

Mouse Alleles Displayer

Gene --> Chromosomal location.

Gene --> GO terms.

Gene --> Overlapping genes.


Gene --> Proteins.


Gene Report --> GWAS hit


0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


Homologue Displayer

Gene --> Orthologues


Cytoscape Network Displayer

Gene --> Physical and Genetic Interactions


Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.



3756 SN Ps

5 Cross References

18 Data Sets

12 Homologues

0 Located Features

97 Rna Seq Results