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Gene : CR1 Homo sapiens

Name  ? complement C3b/C4b receptor 1 (Knops blood group) Cytological Location  1q32.2
Brief Description  complement C3b/C4b receptor 1 (Knops blood group)
Description  This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The genome is polymorphic at this locus with allele-specific splice variants encoding different isoforms, based on the presence/absence of long homologous repeats (LHRs). The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in this gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus, sarcoidosis and Alzheimer's disease. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. [provided by RefSeq, May 2020]
  • synonyms:
  • CD35,
  • C3BR,
  • complement component 3b/4b receptor 1 (Knops blood group),
  • HGNC:2334,
  • KN,
  • OTTHUMG00000036311,
  • uc001hfx.4,
  • complement component (3b/4b) receptor 1, including Knops blood group system,
  • C4BR,
  • CR1,
  • NM_000573,
  • KN,
  • Y00816,
  • complement component (3b/4b) receptor 1 (Knops blood group),
  • CD35
  • identifiers:
  • 1378,
  • ENSG00000203710,
  • CR1

Genome feature

Region: gene ? Length: 145609  
Location: 1:207496157-207641765 Cyto location: 1q32.2

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Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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2 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.



526 SN Ps

5 Cross References

18 Data Sets

4 Homologues

0 Located Features

97 Rna Seq Results