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Gene : ATF2 Homo sapiens

Name  ? activating transcription factor 2 Cytological Location  2q31.1
Brief Description  activating transcription factor 2
Description  This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions This protein binds to the cAMP-responsive element (CRE), an octameric palindrome. It forms a homodimer or a heterodimer with c-Jun and stimulates CRE-dependent transcription. This protein is also a histone acetyltransferase (HAT) that specifically acetylates histones H2B and H4 in vitro; thus it may represent a class of sequence-specific factors that activate transcription by direct effects on chromatin components. The encoded protein may also be involved in cell's DNA damage response independent of its role in transcriptional regulation. Several alternatively spliced transcript variants have been found for this gene [provided by RefSeq, Jan 2014]
  • synonyms:
  • CREB2,
  • CREB2,
  • HGNC:784,
  • CREB-2,
  • TREB7,
  • X15875,
  • CRE-BP1,
  • HB16,
  • HB16,
  • NM_001880,
  • OTTHUMG00000132424,
  • ATF2,
  • cAMP responsive element binding protein 2,
  • TREB7,
  • CRE-BP1,
  • uc010fqu.5
  • identifiers:
  • 1386,
  • ENSG00000115966,
  • ATF2

Genome feature

Region: gene ? Length: 95945  
Location: 2:175072259-175168203 reverse strand Cyto location: 2q31.1

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52 Pathways

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene --> Chromosomal location.

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Gene --> Proteins.


Gene Report --> GWAS hit


0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene --> Physical and Genetic Interactions


Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.



52 Pathways

15 SNPs

5 Cross References

17 Data Sets

7 Homologues

0 Located Features

97 Rna Seq Results