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Gene : CREBL2 Homo sapiens

Name  ? cAMP responsive element binding protein like 2 Cytological Location  12p13.1
Brief Description  cAMP responsive element binding protein like 2
Description  cAMP response element (CRE)-binding protein-like-2 (CREBL2) was identified in a search to find genes in a commonly deleted region on chromosome 12p13 flanked by ETV6 and CDKN1B genes, frequently associated with hematopoietic malignancies, as well as breast, non-small-cell lung and ovarian cancers. CREBL2 shares a 41% identity with CRE-binding protein (CREB) over a 48-base long region which encodes the bZip domain of CREB. The bZip domain consists of about 30 amino acids rich in basic residues involved in DNA binding, followed by a leucine zipper motif involved in protein dimerization. This suggests that CREBL2 encodes a protein with DNA binding capabilities. The occurance of CREBL2 deletion in malignancy suggests that CREBL2 may act as a tumor suppressor gene. [provided by RefSeq, Jul 2008]
  • synonyms:
  • cAMP responsive element binding protein-like 2,
  • OTTHUMG00000168704,
  • NM_001310,
  • uc001rap.3,
  • AF039081,
  • HGNC:2350,
  • CREBL2
  • identifiers:
  • 1389,
  • ENSG00000111269,
  • CREBL2

Genome feature

Region: gene ? Length: 33233  
Location: 12:12611876-12645108 Cyto location: 12p13.1


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Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

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Proteins

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SNPs

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Disease

0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

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Expression

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Other

0 Pathways

162 SN Ps

5 Cross References

16 Data Sets

4 Homologues

0 Located Features

97 Rna Seq Results