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Gene : CRK Homo sapiens

Name  ? CRK proto-oncogene, adaptor protein Cytological Location  17p13.3
Brief Description  CRK proto-oncogene, adaptor protein
Description  This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. [provided by RefSeq, Jul 2008]
  • synonyms:
  • OTTHUMG00000090317,
  • HGNC:2362,
  • CRK,
  • uc002fsl.4,
  • D10656,
  • p38,
  • v-crk avian sarcoma virus CT10 oncogene homolog,
  • NM_016823,
  • CRKII
  • identifiers:
  • 1398,
  • ENSG00000167193,
  • CRK

Genome feature

Region: gene ? Length: 35540  
Location: 17:1420693-1456232 reverse strand Cyto location: 17p13.3


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Proteins

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SNPs

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Disease

0 Diseases

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Expression

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Other

3753 SN Ps

5 Cross References

18 Data Sets

5 Homologues

0 Located Features

97 Rna Seq Results