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Gene : CSK Homo sapiens

Name  ? C-terminal Src kinase Cytological Location  15q24.1
Brief Description  C-terminal Src kinase
Description  The protein encoded by this gene is involved in multiple pathways, including the regulation of Src family kinases. It plays an important role in T-cell activation through its association with the protein encoded by the protein tyrosine phosphatase, non-receptor type 22 (PTPN22) gene. This protein also phosphorylates C-terminal tyrosine residues on multiple substrates, including the protein encoded by the SRC proto-oncogene, non-receptor tyrosine kinase gene. Phosphorylation suppresses the kinase activity of the Src family tyrosine kinases. An intronic polymorphism (rs34933034) in this gene has been found to affect B-cell activation and is associated with systemic lupus erythematosus (SLE). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2017]
  • synonyms:
  • NM_004383,
  • c-src tyrosine kinase,
  • CSK, non-receptor tyrosine kinase,
  • CSK,
  • OTTHUMG00000142814,
  • uc002ays.3,
  • HGNC:2444
  • identifiers:
  • 1445,
  • ENSG00000103653,
  • CSK

Genome feature

Region: gene ? Length: 21119  
Location: 15:74782080-74803198 Cyto location: 15q24.1


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Function

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Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Genomics

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Proteins

Gene --> Proteins.

SNPs

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Disease

0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Homology

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Interactions

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Expression

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Gene Ontology

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Other

3753 SN Ps

5 Cross References

18 Data Sets

5 Homologues

0 Located Features

97 Rna Seq Results