help  | about  | cite  | software

Gene : CTLA4 Homo sapiens

Name  ? cytotoxic T-lymphocyte associated protein 4 Cytological Location  2q33.2
Brief Description  cytotoxic T-lymphocyte associated protein 4
Description  This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. [provided by RefSeq, Jul 2008]
  • synonyms:
  • CTLA-4,
  • CD152,
  • HGNC:2505,
  • insulin-dependent diabetes mellitus 12,
  • CD152,
  • CD,
  • GRD4,
  • IDDM12,
  • CELIAC3,
  • CELIAC3,
  • GSE,
  • CD,
  • NM_005214,
  • GSE,
  • ALPS5,
  • celiac disease 3,
  • OTTHUMG00000132877,
  • CTLA-4,
  • CTLA4,
  • uc002vak.3,
  • IDDM12
  • identifiers:
  • 1493,
  • ENSG00000163599,
  • CTLA4

Genome feature

Region: gene ? Length: 6195  
Location: 2:203867771-203873965 Cyto location: 2q33.2

Uni Prot Comments Displayer

Protein Atlas Displayer

Gene Expression Atlas Tissues Displayer

Gene Expression Atlas Diseases Displayer

Publication Counts Displayer

Curated Proteins Displayer


Gene Ontology Displayer

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


J Browse Displayer

Gene Structure Displayer

Overlapping Features Displayer

Mouse Alleles Displayer

Gene --> Chromosomal location.

Gene --> GO terms.

Gene --> Overlapping genes.


Gene --> Proteins.


Gene Report --> GWAS hit


5 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


Homologue Displayer


Cytoscape Network Displayer

Gene --> Physical and Genetic Interactions


Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.



253 SNPs

5 Cross References

18 Data Sets

5 Homologues

0 Located Features

97 Rna Seq Results