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Gene : CTNNB1 Homo sapiens

Name  ? catenin beta 1 Cytological Location  3p22.1
Brief Description  catenin beta 1
Description  The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]
  • synonyms:
  • armadillo,
  • catenin (cadherin-associated protein), beta 1 (88kD),
  • MRD19,
  • uc010hia.2,
  • OTTHUMG00000131393,
  • EVR7,
  • catenin (cadherin-associated protein), beta 1, 88kDa,
  • CTNNB,
  • HGNC:2514,
  • X87838,
  • armadillo,
  • catenin (cadherin-associated protein), beta 1,
  • CTNNB,
  • CTNNB1,
  • NEDSDV,
  • beta-catenin,
  • NM_001098210
  • identifiers:
  • 1499,
  • ENSG00000168036,
  • CTNNB1

Genome feature

Region: gene ? Length: 41024  
Location: 3:41199422-41240445 Cyto location: 3p22.1


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69 Pathways

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7 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

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69 Pathways

3756 SN Ps

5 Cross References

20 Data Sets

9 Homologues

0 Located Features

97 Rna Seq Results