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Gene : CYP1A1 Homo sapiens

Name  ? cytochrome P450 family 1 subfamily A member 1 Cytological Location  15q24.1
Brief Description  cytochrome P450 family 1 subfamily A member 1
Description  This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2016]
  • synonyms:
  • P450DX,
  • CP11,
  • AHH,
  • CYP1A1,
  • P1-450,
  • OTTHUMG00000142812,
  • P1-450,
  • cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 1,
  • CYPIA1,
  • CYP1,
  • BC023019,
  • P450DX,
  • cytochrome P450, family 1, subfamily A, polypeptide 1,
  • AHRR,
  • NM_000499,
  • uc002ayq.5,
  • P450-C,
  • CP11,
  • HGNC:2595,
  • P450-C,
  • CYP1
  • identifiers:
  • 1543,
  • ENSG00000140465,
  • CYP1A1

Genome feature

Region: gene ? Length: 5987  
Location: 15:74719542-74725528 reverse strand Cyto location: 15q24.1

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0 Diseases

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3740 SNPs

5 Cross References

16 Data Sets

5 Homologues

0 Located Features

97 Rna Seq Results