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Gene : CYP1A2 Homo sapiens

Name  ? cytochrome P450 family 1 subfamily A member 2 Cytological Location  15q24.1
Brief Description  cytochrome P450 family 1 subfamily A member 2
Description  This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. Other xenobiotic substrates for this enzyme include caffeine, aflatoxin B1, and acetaminophen. The transcript from this gene contains four Alu sequences flanked by direct repeats in the 3' untranslated region. [provided by RefSeq, Jul 2008]
  • synonyms:
  • CYP1A2,
  • OTTHUMG00000172901,
  • P3-450,
  • NM_000761,
  • cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 2,
  • CP12,
  • P3-450,
  • uc002ayr.2,
  • CP12,
  • CYPIA2,
  • AF182274,
  • P450(PA),
  • cytochrome P450, family 1, subfamily A, polypeptide 2,
  • HGNC:2596
  • identifiers:
  • 1544,
  • ENSG00000140505,
  • CYP1A2

Genome feature

Region: gene ? Length: 7763  
Location: 15:74748845-74756607 Cyto location: 15q24.1

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Gene -> HPO annotation (Human Phenotype Ontology)

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0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene Ontology

Gene --> GO terms.



23 SN Ps

5 Cross References

17 Data Sets

1 Homologues

0 Located Features

97 Rna Seq Results