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Gene : CYP2A6 Homo sapiens

Name  ? cytochrome P450 family 2 subfamily A member 6 Cytological Location  19q13.2
Brief Description  cytochrome P450 family 2 subfamily A member 6
Description  This gene, CYP2A6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to hydroxylate coumarin, and also metabolizes nicotine, aflatoxin B1, nitrosamines, and some pharmaceuticals. Individuals with certain allelic variants are said to have a poor metabolizer phenotype, meaning they do not efficiently metabolize coumarin or nicotine. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. The gene was formerly referred to as CYP2A3; however, it has been renamed CYP2A6. [provided by RefSeq, Jul 2008]
  • synonyms:
  • HGNC:2610,
  • CYP2A6,
  • CYP2A3,
  • cytochrome P450, family 2, subfamily A, polypeptide 6,
  • CYPIIA6,
  • P450C2A,
  • cytochrome P450, subfamily IIA (phenobarbital-inducible), polypeptide 6,
  • CYP2A,
  • uc002opl.4,
  • CYP2A,
  • CPA6,
  • CPA6,
  • AF182275,
  • OTTHUMG00000182713,
  • CYP2A3,
  • P450PB,
  • NM_000762
  • identifiers:
  • 1548,
  • ENSG00000255974,
  • CYP2A6

Genome feature

Region: gene ? Length: 6907  
Location: 19:40843541-40850447 reverse strand Cyto location: 19q13.2


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Function

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Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Genomics

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Proteins

Gene --> Proteins.

SNPs

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Disease

3 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Homology

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Interactions

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Expression

Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

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Other

212 SN Ps

5 Cross References

17 Data Sets

47 Homologues

0 Located Features

97 Rna Seq Results