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Gene : CYP2C19 Homo sapiens

Name  ? cytochrome P450 family 2 subfamily C member 19 Cytological Location  10q23.33
Brief Description  cytochrome P450 family 2 subfamily C member 19
Description  This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, omeprazole, diazepam and some barbiturates. Polymorphism within this gene is associated with variable ability to metabolize mephenytoin, known as the poor metabolizer and extensive metabolizer phenotypes. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. [provided by RefSeq, Jul 2008]
  • synonyms:
  • cytochrome P450, family 2, subfamily C, polypeptide 19,
  • CPCJ,
  • CYPIIC19,
  • cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 19,
  • P450IIC19,
  • CYP2C,
  • uc010qnz.3,
  • CYP2C19,
  • M61854,
  • CYPIIC17,
  • P450C2C,
  • P450IIC19,
  • HGNC:2621,
  • NM_000769,
  • CYP2C,
  • OTTHUMG00000018799,
  • CPCJ
  • identifiers:
  • 1557,
  • ENSG00000165841,
  • CYP2C19

Genome feature

Region: gene ? Length: 92867  
Location: 10:94762681-94855547 Cyto location: 10q23.33

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Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene --> Proteins.


Gene Report --> GWAS hit


1 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene --> Physical and Genetic Interactions


Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.



3740 SN Ps

5 Cross References

17 Data Sets

42 Homologues

0 Located Features

97 Rna Seq Results