help  | about  | cite  | software

Gene : CYP2C19 Homo sapiens

Name  ? cytochrome P450 family 2 subfamily C member 19 Cytological Location  10q23.33
Brief Description  cytochrome P450 family 2 subfamily C member 19
Description  This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, omeprazole, diazepam and some barbiturates. Polymorphism within this gene is associated with variable ability to metabolize mephenytoin, known as the poor metabolizer and extensive metabolizer phenotypes. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. [provided by RefSeq, Jul 2008]
  • synonyms:
  • cytochrome P450, family 2, subfamily C, polypeptide 19,
  • CPCJ,
  • CYPIIC19,
  • cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 19,
  • P450IIC19,
  • CYP2C,
  • uc010qnz.3,
  • CYP2C19,
  • M61854,
  • CYPIIC17,
  • P450C2C,
  • P450IIC19,
  • HGNC:2621,
  • NM_000769,
  • CYP2C,
  • OTTHUMG00000018799,
  • CPCJ
  • identifiers:
  • 1557,
  • ENSG00000165841,
  • CYP2C19

Genome feature

Region: gene ? Length: 92867  
Location: 10:94762681-94855547 Cyto location: 10q23.33


Uni Prot Comments Displayer

Protein Atlas Displayer

Gene Expression Atlas Tissues Displayer

Gene Expression Atlas Diseases Displayer

Publication Counts Displayer

Curated Proteins Displayer

Function

Gene Ontology Displayer

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Genomics

J Browse Displayer

Gene Structure Displayer

Overlapping Features Displayer

Mouse Alleles Displayer

Gene --> Chromosomal location.

Gene --> GO terms.

Gene --> Overlapping genes.

Proteins

Gene --> Proteins.

SNPs

Gene Report --> GWAS hit

Disease

1 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Homology

Homologue Displayer

Interactions

Cytoscape Network Displayer

Gene --> Physical and Genetic Interactions

Expression

Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.

 

Other

3740 SN Ps

5 Cross References

17 Data Sets

42 Homologues

0 Located Features

97 Rna Seq Results