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Gene : CYP2E1 Homo sapiens
Name  ? cytochrome P450 family 2 subfamily E member 1 Cytological Location  10q26.3
Brief Description  cytochrome P450 family 2 subfamily E member 1
Description  This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, as well as exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines which are premutagens found in cigarette smoke. Due to its many substrates, this enzyme may be involved in such varied processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer. [provided by RefSeq, Jul 2008]
  • synonyms:
  • P450-J,
  • P450C2E,
  • CPE1,
  • CYP2E1,
  • CYP2E,
  • HGNC:2631,
  • NM_000773,
  • OTTHUMG00000019322,
  • uc057xaa.1,
  • cytochrome P450, subfamily IIE (ethanol-inducible), polypeptide 1,
  • J02843,
  • cytochrome P450, family 2, subfamily E, polypeptide 1,
  • CYP2E
  • identifiers:
  • 1571,
  • ENSG00000130649,
  • CYP2E1

Genome feature

Region: gene ? Length: 11761  
Location: 10:133527363-133539123 Cyto location: 10q26.3


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Lists
This Gene is in one list:
PL_BHF_UCL_cardiovascGenes (4103)

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Function

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11 Pathways

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Genomics

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Gene --> Chromosomal location.

Gene --> GO terms.

Gene --> Overlapping genes.

Proteins

Gene --> Proteins.

SNPs

Gene Report --> GWAS hit

Disease

0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Homology

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Interactions

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Gene --> Physical and Genetic Interactions

Expression

Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.

 

Other

11 Pathways

3740 SNPs

5 Cross References

17 Data Sets

42 Homologues

0 Located Features

97 Rna Seq Results





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