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Gene : CYP3A4 Homo sapiens

Name  ? cytochrome P450 family 3 subfamily A member 4 Cytological Location  7q22.1
Brief Description  cytochrome P450 family 3 subfamily A member 4
Description  This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs in use today, including acetaminophen, codeine, cyclosporin A, diazepam, erythromycin, and chloroquine. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2020]
  • synonyms:
  • P450PCN1,
  • HLP,
  • cytochrome P450, family 3, subfamily A, polypeptide 4,
  • CP34,
  • NM_001202855,
  • CYP3A3,
  • cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4,
  • OTTHUMG00000156651,
  • CYP3A,
  • VDDR3,
  • uc064fwx.1,
  • HGNC:2637,
  • CYP3A3,
  • CYP3A4,
  • NF-25,
  • CP33,
  • P450C3,
  • AF280107
  • identifiers:
  • 1576,
  • ENSG00000160868,
  • CYP3A4

Genome feature

Region: gene ? Length: 27218  
Location: 7:99756967-99784184 reverse strand Cyto location: 7q22.1

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1 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

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Gene Ontology

Gene --> GO terms.



147 SNPs

5 Cross References

19 Data Sets

17 Homologues

0 Located Features

97 Rna Seq Results