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Gene : DAB2 Homo sapiens

Name  ? DAB adaptor protein 2 Cytological Location  5p13.1
Brief Description  DAB adaptor protein 2
Description  This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
  • synonyms:
  • DOC-2,
  • Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila),
  • DOC-2,
  • HGNC:2662,
  • disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila),
  • U53446,
  • uc003jlx.4,
  • NM_001343,
  • DAB2,
  • DOC2,
  • OTTHUMG00000162043,
  • disabled (Drosophila) homolog 2 (mitogen-responsive phosphoprotein),
  • DAB2, clathrin adaptor protein
  • identifiers:
  • 1601,
  • ENSG00000153071,
  • DAB2

Genome feature

Region: gene ? Length: 53560  
Location: 5:39371674-39425233 reverse strand Cyto location: 5p13.1


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5 Cross References

10 Data Sets

6 Homologues

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