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Gene : DAZL Homo sapiens

Name  ? deleted in azoospermia like Cytological Location  3p24.3
Brief Description  deleted in azoospermia like
Description  The DAZ (Deleted in AZoospermia) gene family encodes potential RNA binding proteins that are expressed in prenatal and postnatal germ cells of males and females. The protein encoded by this gene is localized to the nucleus and cytoplasm of fetal germ cells and to the cytoplasm of developing oocytes. In the testis, this protein is localized to the nucleus of spermatogonia but relocates to the cytoplasm during meiosis where it persists in spermatids and spermatozoa. Transposition and amplification of this autosomal gene during primate evolution gave rise to the DAZ gene cluster on the Y chromosome. Mutations in this gene have been linked to severe spermatogenic failure and infertility in males. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
  • synonyms:
  • BC027595,
  • OTTHUMG00000157050,
  • DAZLA,
  • DAZH,
  • SPGYLA,
  • DAZH,
  • DAZL1,
  • deleted in azoospermia-like,
  • HGNC:2685,
  • NM_001351,
  • uc062hfm.1,
  • DAZL1,
  • MGC26406,
  • DAZL,
  • SPGYLA,
  • DAZLA
  • identifiers:
  • 1618,
  • ENSG00000092345,
  • DAZL

Genome feature

Region: gene ? Length: 18632  
Location: 3:16586792-16605423 reverse strand Cyto location: 3p24.3


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Function

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0 Pathways

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Genomics

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Proteins

Gene --> Proteins.

SNPs

Gene Report --> GWAS hit

Disease

0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

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Expression

Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.

 

Other

0 Pathways

32 SN Ps

5 Cross References

17 Data Sets

5 Homologues

0 Located Features

97 Rna Seq Results