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Gene : DCC Homo sapiens

Name  ? DCC netrin 1 receptor Cytological Location  18q21.2
Brief Description  DCC netrin 1 receptor
Description  This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma. [provided by RefSeq, Oct 2009]
  • synonyms:
  • NTN1R1,
  • CRCR1,
  • immunoglobulin superfamily, DCC subclass, member 1,
  • HGNC:2701,
  • IGDCC1,
  • IGDCC1,
  • OTTHUMG00000132698,
  • DCC,
  • CRC18,
  • MRMV1,
  • HGPPS2,
  • deleted in colorectal carcinoma,
  • X76132,
  • NTN1R1,
  • NM_005215,
  • uc002lfe.3
  • identifiers:
  • 1630,
  • ENSG00000187323,
  • DCC

Genome feature

Region: gene ? Length: 1195728  
Location: 18:52340172-53535899 Cyto location: 18q21.2

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4 Diseases

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3753 SN Ps

5 Cross References

20 Data Sets

8 Homologues

1 Located Features

97 Rna Seq Results