help  | about  | cite  | software

Gene : DCC Homo sapiens

Name  ? DCC netrin 1 receptor Cytological Location  18q21.2
Brief Description  DCC netrin 1 receptor
Description  This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma. [provided by RefSeq, Oct 2009]
  • synonyms:
  • NTN1R1,
  • CRCR1,
  • immunoglobulin superfamily, DCC subclass, member 1,
  • HGNC:2701,
  • IGDCC1,
  • IGDCC1,
  • OTTHUMG00000132698,
  • DCC,
  • CRC18,
  • MRMV1,
  • HGPPS2,
  • deleted in colorectal carcinoma,
  • X76132,
  • NTN1R1,
  • NM_005215,
  • uc002lfe.3
  • identifiers:
  • 1630,
  • ENSG00000187323,
  • DCC

Genome feature

Region: gene ? Length: 1195728  
Location: 18:52340172-53535899 Cyto location: 18q21.2


Uni Prot Comments Displayer

Protein Atlas Displayer

Gene Expression Atlas Tissues Displayer

Gene Expression Atlas Diseases Displayer

Publication Counts Displayer

Curated Proteins Displayer

Function

Gene Ontology Displayer

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Genomics

J Browse Displayer

Gene Structure Displayer

Overlapping Features Displayer

Mouse Alleles Displayer

Gene --> Chromosomal location.

Gene --> GO terms.

Gene --> Overlapping genes.

Proteins

Gene --> Proteins.

SNPs

Gene Report --> GWAS hit

Disease

4 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Homology

Homologue Displayer

Interactions

Cytoscape Network Displayer

Gene --> Physical and Genetic Interactions

Expression

Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.

 

Other

3753 SN Ps

5 Cross References

20 Data Sets

8 Homologues

1 Located Features

97 Rna Seq Results