help  | about  | cite  | software

Gene : DENND1B Homo sapiens

Name  ? DENN domain containing 1B Cytological Location  1q31.3
Brief Description  DENN domain containing 1B
Description  Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1B, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 [PubMed 20154091]).[supplied by OMIM, Nov 2010]
  • synonyms:
  • NM_144977,
  • connecdenn 2,
  • FAM31B,
  • MGC27044,
  • OTTHUMG00000035653,
  • chromosome 1 open reading frame 218,
  • C1orf218,
  • DENND1B,
  • uc001guf.4,
  • family with sequence similarity 31, member B,
  • C1ORF18,
  • HGNC:28404,
  • BC016588,
  • DENN/MADD domain containing 1B,
  • FLJ20054,
  • C1orf218,
  • FAM31B
  • identifiers:
  • 163486,
  • ENSG00000213047,
  • DENND1B

Genome feature

Region: gene ? Length: 277391  
Location: 1:197504748-197782138 reverse strand Cyto location: 1q31.3


Uni Prot Comments Displayer

Protein Atlas Displayer

Gene Expression Atlas Tissues Displayer

Gene Expression Atlas Diseases Displayer

Publication Counts Displayer

Curated Proteins Displayer

Function

Gene Ontology Displayer

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Genomics

J Browse Displayer

Gene Structure Displayer

Overlapping Features Displayer

Mouse Alleles Displayer

Gene --> Chromosomal location.

Gene --> GO terms.

Gene --> Overlapping genes.

Proteins

Gene --> Proteins.

SNPs

Gene Report --> GWAS hit

Disease

0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Homology

Homologue Displayer

Interactions

Cytoscape Network Displayer

Gene --> Physical and Genetic Interactions

Expression

Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.

 

Other

3753 SN Ps

5 Cross References

17 Data Sets

4 Homologues

0 Located Features

97 Rna Seq Results