help  | about  | cite  | software

Gene : DDIT3 Homo sapiens

Name  ? DNA damage inducible transcript 3 Cytological Location  12q13.3
Brief Description  DNA damage inducible transcript 3
Description  This gene encodes a member of the CCAAT/enhancer-binding protein (C/EBP) family of transcription factors. The protein functions as a dominant-negative inhibitor by forming heterodimers with other C/EBP members, such as C/EBP and LAP (liver activator protein), and preventing their DNA binding activity. The protein is implicated in adipogenesis and erythropoiesis, is activated by endoplasmic reticulum stress, and promotes apoptosis. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in myxoid liposarcomas or Ewing sarcoma. Multiple alternatively spliced transcript variants encoding two isoforms with different length have been identified. [provided by RefSeq, Aug 2010]
  • synonyms:
  • AltDDIT3,
  • NM_004083,
  • C/EBP zeta,
  • CHOP,
  • BC003637,
  • DNA-damage-inducible transcript 3,
  • GADD153,
  • CHOP-10,
  • CEBPZ,
  • GADD153,
  • HGNC:2726,
  • C/EBPzeta,
  • CHOP,
  • uc001soi.4,
  • OTTHUMG00000170046,
  • CHOP10,
  • CHOP10,
  • DDIT3
  • identifiers:
  • 1649,
  • ENSG00000175197,
  • DDIT3

Genome feature

Region: gene ? Length: 3930  
Location: 12:57516588-57520517 reverse strand Cyto location: 12q13.3


Uni Prot Comments Displayer

Protein Atlas Displayer

Gene Expression Atlas Tissues Displayer

Gene Expression Atlas Diseases Displayer

Publication Counts Displayer

Curated Proteins Displayer

Function

Gene Ontology Displayer

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Genomics

J Browse Displayer

Gene Structure Displayer

Overlapping Features Displayer

Mouse Alleles Displayer

Gene --> Chromosomal location.

Gene --> GO terms.

Gene --> Overlapping genes.

Proteins

Gene --> Proteins.

SNPs

Gene Report --> GWAS hit

Disease

0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Homology

Homologue Displayer

Interactions

Cytoscape Network Displayer

Gene --> Physical and Genetic Interactions

Expression

Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.

 

Other

204 SN Ps

5 Cross References

17 Data Sets

3 Homologues

0 Located Features

97 Rna Seq Results