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Gene : DDX3X Homo sapiens

Name  ? DEAD-box helicase 3 X-linked Cytological Location  Xp11.4
Brief Description  DEAD-box helicase 3 X-linked
Description  The protein encoded by this gene is a member of the large DEAD-box protein family, that is defined by the presence of the conserved Asp-Glu-Ala-Asp (DEAD) motif, and has ATP-dependent RNA helicase activity. This protein has been reported to display a high level of RNA-independent ATPase activity, and unlike most DEAD-box helicases, the ATPase activity is thought to be stimulated by both RNA and DNA. This protein has multiple conserved domains and is thought to play roles in both the nucleus and cytoplasm. Nuclear roles include transcriptional regulation, mRNP assembly, pre-mRNA splicing, and mRNA export. In the cytoplasm, this protein is thought to be involved in translation, cellular signaling, and viral replication. Misregulation of this gene has been implicated in tumorigenesis. This gene has a paralog located in the nonrecombining region of the Y chromosome. Pseudogenes sharing similarity to both this gene and the DDX3Y paralog are found on chromosome 4 and the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
  • synonyms:
  • DDX3,
  • DBX,
  • OTTHUMG00000021369,
  • DDX3,
  • HGNC:2745,
  • MRX102,
  • HLP2,
  • uc033eaf.2,
  • U50553,
  • DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked,
  • DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked,
  • DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3,
  • CAP-Rf,
  • DDX14,
  • DDX14,
  • DBX,
  • DDX3X,
  • HLP2,
  • NM_024005
  • identifiers:
  • 1654,
  • ENSG00000215301,
  • DDX3X

Genome feature

Region: gene ? Length: 31165  
Location: X:41333308-41364472 Cyto location: Xp11.4


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Disease

1 Diseases

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Expression

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3753 SN Ps

5 Cross References

19 Data Sets

17 Homologues

0 Located Features

97 Rna Seq Results