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Gene : DR1 Homo sapiens

Name  ? down-regulator of transcription 1 Cytological Location  1p22.1
Brief Description  down-regulator of transcription 1
Description  This gene encodes a TBP- (TATA box-binding protein) associated phosphoprotein that represses both basal and activated levels of transcription. The encoded protein is phosphorylated in vivo and this phosphorylation affects its interaction with TBP. This protein contains a histone fold motif at the amino terminus, a TBP-binding domain, and a glutamine- and alanine-rich region. The binding of DR1 repressor complexes to TBP-promoter complexes may establish a mechanism in which an altered DNA conformation, together with the formation of higher order complexes, inhibits the assembly of the preinitiation complex and controls the rate of RNA polymerase II transcription. [provided by RefSeq, Jul 2008]
  • synonyms:
  • NC2B,
  • DR1,
  • down-regulator of transcription 1, TBP-binding (negative cofactor 2),
  • NC2,
  • OTTHUMG00000010862,
  • uc001dpu.4,
  • NM_001938,
  • HGNC:3017,
  • NCB2,
  • negative cofactor 2 beta,
  • NC2B,
  • NCB2,
  • NC2-BETA,
  • NC2-BETA,
  • negative cofactor 2,
  • M97388
  • identifiers:
  • 1810,
  • ENSG00000117505,
  • DR1

Genome feature

Region: gene ? Length: 23587  
Location: 1:93345907-93369493 Cyto location: 1p22.1

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3753 SN Ps

5 Cross References

16 Data Sets

6 Homologues

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97 Rna Seq Results