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Gene : AGT Homo sapiens

Name  ? angiotensinogen Cytological Location  1q42.2
Brief Description  angiotensinogen
Description  The protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure, body fluid and electrolyte homeostasis, and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease. [provided by RefSeq, Nov 2019]
  • synonyms:
  • NM_000029,
  • K02215,
  • hFLT1,
  • HGNC:333,
  • alpha-1 antiproteinase, antitrypsin,
  • serpin peptidase inhibitor, clade A, member 8,
  • OTTHUMG00000037757,
  • uc001hty.6,
  • AGT,
  • ANHU
  • identifiers:
  • 183,
  • ENSG00000135744,
  • AGT

Genome feature

Region: gene ? Length: 43061  
Location: 1:230702523-230745583 reverse strand Cyto location: 1q42.2

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2 Diseases

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3740 SNPs

5 Cross References

19 Data Sets

41 Homologues

0 Located Features

97 Rna Seq Results