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Gene : DUSP5 Homo sapiens

Name  ? dual specificity phosphatase 5 Cytological Location  10q25.2
Brief Description  dual specificity phosphatase 5
Description  The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, is expressed in a variety of tissues with the highest levels in pancreas and brain, and is localized in the nucleus. [provided by RefSeq, Jul 2008]
  • synonyms:
  • OTTHUMG00000019040,
  • DUSP5,
  • NM_004419,
  • U16996,
  • uc001kzd.4,
  • HVH3,
  • HGNC:3071,
  • HVH3,
  • DUSP
  • identifiers:
  • 1847,
  • ENSG00000138166,
  • DUSP5

Genome feature

Region: gene ? Length: 13627  
Location: 10:110497907-110511533 Cyto location: 10q25.2


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Disease

0 Diseases

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Other

48 SN Ps

5 Cross References

17 Data Sets

3 Homologues

0 Located Features

97 Rna Seq Results