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Gene : DUSP7 Homo sapiens

Name  ? dual specificity phosphatase 7 Cytological Location  3p21.2
Brief Description  dual specificity phosphatase 7
Description  Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. DUSP7 belongs to a class of DUSPs, designated MKPs, that dephosphorylate MAPK (mitogen-activated protein kinase) proteins ERK (see MIM 601795), JNK (see MIM 601158), and p38 (see MIM 600289) with specificity distinct from that of individual MKP proteins. MKPs contain a highly conserved C-terminal catalytic domain and an N-terminal Cdc25 (see MIM 116947)-like (CH2) domain. MAPK activation cascades mediate various physiologic processes, including cellular proliferation, apoptosis, differentiation, and stress responses (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009]
  • synonyms:
  • PYST2,
  • DUSP7,
  • uc003dct.4,
  • MKPX,
  • X93921,
  • HGNC:3073,
  • OTTHUMG00000157819,
  • NM_001947,
  • MKP-X,
  • PYST2
  • identifiers:
  • 1849,
  • ENSG00000164086,
  • DUSP7

Genome feature

Region: gene ? Length: 7653  
Location: 3:52048919-52056571 reverse strand Cyto location: 3p21.2


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Disease

0 Diseases

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Other

155 SN Ps

5 Cross References

16 Data Sets

5 Homologues

0 Located Features

97 Rna Seq Results