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Gene : DYRK1A Homo sapiens

Name  ? dual specificity tyrosine phosphorylation regulated kinase 1A Cytological Location  21q22.13
Brief Description  dual specificity tyrosine phosphorylation regulated kinase 1A
Description  This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms. [provided by RefSeq, Jul 2008]
  • synonyms:
  • NM_001396,
  • uc002ywk.4,
  • DYRK,
  • dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A,
  • U52373,
  • DYRK1,
  • MNBH,
  • MNB,
  • HGNC:3091,
  • DYRK1,
  • HP86,
  • MNBH,
  • DYRK,
  • dual specificity tyrosine-(Y)-phosphorylation regulated kinase 1A,
  • MRD7,
  • OTTHUMG00000086657,
  • DYRK1A
  • identifiers:
  • 1859,
  • ENSG00000157540,
  • DYRK1A

Genome feature

Region: gene ? Length: 160786  
Location: 21:37365573-37526358 Cyto location: 21q22.13


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Disease

1 Diseases

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3753 SN Ps

5 Cross References

19 Data Sets

6 Homologues

0 Located Features

97 Rna Seq Results