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Gene : EDN1 Homo sapiens

Name  ? endothelin 1 Cytological Location  6p24.1
Brief Description  endothelin 1
Description  This gene encodes a preproprotein that is proteolytically processed to generate a secreted peptide that belongs to the endothelin/sarafotoxin family. This peptide is a potent vasoconstrictor and its cognate receptors are therapeutic targets in the treatment of pulmonary arterial hypertension. Aberrant expression of this gene may promote tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
  • synonyms:
  • ET1,
  • QME,
  • S56805,
  • NM_001955,
  • HDLCQ7,
  • OTTHUMG00000014266,
  • ARCND3,
  • HGNC:3176,
  • EDN1,
  • PPET1,
  • uc003nae.5,
  • ET1
  • identifiers:
  • 1906,
  • ENSG00000078401,
  • EDN1

Genome feature

Region: gene ? Length: 40732  
Location: 6:12256463-12297194 Cyto location: 6p24.1

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Gene -> HPO annotation (Human Phenotype Ontology)

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2 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.



56 SN Ps

5 Cross References

20 Data Sets

3 Homologues

0 Located Features

97 Rna Seq Results