help  | about  | cite  | software

Gene : EFNA5 Homo sapiens

Name  ? ephrin A5 Cytological Location  5q21.3
Brief Description  ephrin A5
Description  Ephrin-A5, a member of the ephrin gene family, prevents axon bundling in cocultures of cortical neurons with astrocytes, a model of late stage nervous system development and differentiation. The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, particularly in the nervous system. EPH receptors typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin ligands and receptors have been named by the Eph Nomenclature Committee (1997). Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are similarly divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. [provided by RefSeq, Jul 2008]
  • synonyms:
  • EPH-related receptor tyrosine kinase ligand 7,
  • EPLG7,
  • U26403,
  • GLC1M,
  • LERK7,
  • RAGS,
  • AF1,
  • uc003kol.3,
  • EFNA5,
  • HGNC:3225,
  • NM_001962,
  • ephrin-A5,
  • EFL5,
  • EPLG7,
  • OTTHUMG00000128741,
  • LERK7,
  • AF1
  • identifiers:
  • 1946,
  • ENSG00000184349,
  • EFNA5

Genome feature

Region: gene ? Length: 294049  
Location: 5:107376889-107670937 reverse strand Cyto location: 5q21.3


Uni Prot Comments Displayer

Protein Atlas Displayer

Gene Expression Atlas Tissues Displayer

Gene Expression Atlas Diseases Displayer

Publication Counts Displayer

Curated Proteins Displayer

Function

Gene Ontology Displayer

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Genomics

J Browse Displayer

Gene Structure Displayer

Overlapping Features Displayer

Mouse Alleles Displayer

Gene --> Chromosomal location.

Gene --> GO terms.

Gene --> Overlapping genes.

Proteins

Gene --> Proteins.

SNPs

Gene Report --> GWAS hit

Disease

0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Homology

Homologue Displayer

Interactions

Cytoscape Network Displayer

Gene --> Physical and Genetic Interactions

Expression

Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.

 

Other

675 SN Ps

5 Cross References

17 Data Sets

9 Homologues

7 Located Features

97 Rna Seq Results