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Gene : EGF Homo sapiens

Name  ? epidermal growth factor Cytological Location  4q25
Brief Description  epidermal growth factor
Description  This gene encodes a member of the epidermal growth factor superfamily. The encoded preproprotein is proteolytically processed to generate the 53-amino acid epidermal growth factor peptide. This protein acts a potent mitogenic factor that plays an important role in the growth, proliferation and differentiation of numerous cell types. This protein acts by binding with high affinity to the cell surface receptor, epidermal growth factor receptor. Defects in this gene are the cause of hypomagnesemia type 4. Dysregulation of this gene has been associated with the growth and progression of certain cancers. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016]
  • synonyms:
  • URG,
  • uc003hzy.5,
  • epidermal growth factor (beta-urogastrone),
  • NM_001178130,
  • OTTHUMG00000132044,
  • EGF,
  • HOMG4,
  • HGNC:3229,
  • X04571,
  • Pro-epidermal growth factor
  • identifiers:
  • 1950,
  • ENSG00000138798,
  • EGF

Genome feature

Region: gene ? Length: 100884  
Location: 4:109912883-110013766 Cyto location: 4q25


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Function

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75 Pathways

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Genomics

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Gene --> Chromosomal location.

Gene --> GO terms.

Gene --> Overlapping genes.

Proteins

Gene --> Proteins.

SNPs

Gene Report --> GWAS hit

Disease

1 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Homology

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Interactions

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Gene --> Physical and Genetic Interactions

Expression

Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.

 

Other

75 Pathways

3753 SN Ps

5 Cross References

19 Data Sets

5 Homologues

2 Located Features

97 Rna Seq Results