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Gene : EIF4E Homo sapiens

Name  ? eukaryotic translation initiation factor 4E Cytological Location  4q23
Brief Description  eukaryotic translation initiation factor 4E
Description  The protein encoded by this gene is a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5' end of messenger RNAs. The encoded protein aids in translation initiation by recruiting ribosomes to the 5'-cap structure. Association of this protein with the 4F complex is the rate-limiting step in translation initiation. This gene acts as a proto-oncogene, and its expression and activation is associated with transformation and tumorigenesis. Several pseudogenes of this gene are found on other chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
  • synonyms:
  • HGNC:3287,
  • CBP,
  • EIF4F,
  • uc003hue.3,
  • AUTS19,
  • EIF4E1,
  • EIF4E,
  • NM_001968,
  • EIF4EL1,
  • EIF4F,
  • M15353,
  • eIF-4E,
  • OTTHUMG00000161090,
  • EIF4E1,
  • EIF4EL1
  • identifiers:
  • 1977,
  • ENSG00000151247,
  • EIF4E

Genome feature

Region: gene ? Length: 58954  
Location: 4:98871684-98930637 reverse strand Cyto location: 4q23


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Function

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Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Genomics

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Gene --> Chromosomal location.

Gene --> GO terms.

Gene --> Overlapping genes.

Proteins

Gene --> Proteins.

SNPs

Gene Report --> GWAS hit

Disease

1 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Homology

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Interactions

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Expression

Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.

 

Other

3753 SN Ps

5 Cross References

19 Data Sets

15 Homologues

0 Located Features

97 Rna Seq Results