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Gene : EIF4EBP1 Homo sapiens

Name  ? eukaryotic translation initiation factor 4E binding protein 1 Cytological Location  8p11.23
Brief Description  eukaryotic translation initiation factor 4E binding protein 1
Description  This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. [provided by RefSeq, Jul 2008]
  • synonyms:
  • PHAS-I,
  • 4E-BP1,
  • uc003xks.4,
  • phosphorylated heat- and acid-stable protein regulated by insulin 1,
  • 4E-BP1,
  • PHAS-I,
  • NM_004095,
  • OTTHUMG00000164012,
  • BP-1,
  • EIF4EBP1,
  • 4EBP1,
  • HGNC:3288
  • identifiers:
  • 1978,
  • ENSG00000187840,
  • EIF4EBP1

Genome feature

Region: gene ? Length: 29832  
Location: 8:38030534-38060365 Cyto location: 8p11.23


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Function

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Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Genomics

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Gene --> GO terms.

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Proteins

Gene --> Proteins.

SNPs

Gene Report --> GWAS hit

Disease

0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Homology

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Interactions

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Expression

Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

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Other

126 SN Ps

5 Cross References

17 Data Sets

4 Homologues

0 Located Features

97 Rna Seq Results