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Gene : DAND5 Homo sapiens

Name  ? DAN domain BMP antagonist family member 5 Cytological Location  19p13.13
Brief Description  DAN domain BMP antagonist family member 5
Description  This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to bind Nodal and to inhibit the Nodal signaling pathway which patterns left/right body asymmetry. [provided by RefSeq, Jul 2008]
  • synonyms:
  • SP1,
  • DTE,
  • GREM3,
  • COCO,
  • GREM3,
  • CER2,
  • CER2,
  • CERL2,
  • CRL2,
  • DAND5,
  • AK095926,
  • CKTSF1B3,
  • DAN domain family member 5, BMP antagonist,
  • HGNC:26780,
  • NM_152654,
  • Coco,
  • DANTE,
  • CKTSF1B3,
  • uc002mwc.2,
  • DANTE,
  • FLJ38607,
  • OTTHUMG00000180725
  • identifiers:
  • 199699,
  • ENSG00000179284,
  • DAND5

Genome feature

Region: gene ? Length: 5185  
Location: 19:12969576-12974760 Cyto location: 19p13.13

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Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene --> Chromosomal location.

Gene --> GO terms.

Gene --> Overlapping genes.


Gene --> Proteins.


Gene Report --> GWAS hit


0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene --> Physical and Genetic Interactions


Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.



64 SN Ps

4 Cross References

12 Data Sets

3 Homologues

0 Located Features

97 Rna Seq Results