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Gene : CERS3 Homo sapiens

Name  ? ceramide synthase 3 Cytological Location  15q26.3
Brief Description  ceramide synthase 3
Description  This gene is a member of the ceramide synthase family of genes. The ceramide synthase enzymes regulate sphingolipid synthesis by catalyzing the formation of ceramides from sphingoid base and acyl-coA substrates. This family member is involved in the synthesis of ceramides with ultra-long-chain acyl moieties (ULC-Cers), important to the epidermis in its role in creating a protective barrier from the environment. The protein encoded by this gene has also been implicated in modification of the lipid structures required for spermatogenesis. Mutations in this gene have been associated with male fertility defects, and epidermal defects, including ichthyosis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]
  • synonyms:
  • uc002bwb.3,
  • MGC27091,
  • LASS3,
  • CERS3,
  • NM_178842,
  • OTTHUMG00000172568,
  • LAG1 longevity assurance homolog 3 (S. cerevisiae),
  • HGNC:23752,
  • LAG1 homolog, ceramide synthase 3,
  • ARCI9,
  • LASS3
  • identifiers:
  • 204219,
  • ENSG00000154227,
  • CERS3

Genome feature

Region: gene ? Length: 144588  
Location: 15:100400395-100544982 reverse strand Cyto location: 15q26.3


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Disease

1 Diseases

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3753 SN Ps

5 Cross References

18 Data Sets

11 Homologues

0 Located Features

97 Rna Seq Results