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Gene : ERBB3 Homo sapiens

Name  ? erb-b2 receptor tyrosine kinase 3 Cytological Location  12q13.2
Brief Description  erb-b2 receptor tyrosine kinase 3
Description  This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
  • synonyms:
  • HER3,
  • c-erbB-3,
  • p45-sErbB3,
  • LCCS2,
  • human epidermal growth factor receptor 3,
  • p85-sErbB3,
  • FERLK,
  • NM_001982,
  • c-erbB3,
  • MDA-BF-1,
  • OTTHUMG00000170140,
  • erbB3-S,
  • HER3,
  • lethal congenital contracture syndrome 2,
  • ErbB-3,
  • ERBB3,
  • M34309,
  • p180-ErbB3,
  • uc001sjh.4,
  • v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3,
  • HGNC:3431,
  • LCCS2
  • identifiers:
  • 2065,
  • ENSG00000065361,
  • ERBB3

Genome feature

Region: gene ? Length: 23398  
Location: 12:56080108-56103505 Cyto location: 12q13.2


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Disease

2 Diseases

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45 SN Ps

5 Cross References

20 Data Sets

6 Homologues

0 Located Features

97 Rna Seq Results