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Gene : ERN1 Homo sapiens

Name  ? endoplasmic reticulum to nucleus signaling 1 Cytological Location  17q23.3
Brief Description  endoplasmic reticulum to nucleus signaling 1
Description  This gene encodes the transmembrane protein kinase inositol-requiring enzyme 1. The encoded protein contains two functional catalytic domains, a serine/threonine-protein kinase domain and an endoribonuclease domain. This protein functions as a sensor of unfolded proteins in the endoplasmic reticulum (ER) and triggers an intracellular signaling pathway termed the unfolded protein response (UPR). The UPR is an ER stress response that is conserved from yeast to mammals and activates genes involved in degrading misfolded proteins, regulating protein synthesis and activating molecular chaperones. This protein specifically mediates the splicing and activation of the stress response transcription factor X-box binding protein 1. [provided by RefSeq, Aug 2017]
  • synonyms:
  • hIRE1p,
  • IRE1,
  • Serine/threonine-protein kinase/endoribonuclease IRE1,
  • IRE1P,
  • NM_001433,
  • ERN1,
  • uc002jdz.3,
  • OTTHUMG00000178879,
  • IRE1P,
  • HGNC:3449,
  • inositol-requiring enzyme 1,
  • AF059198,
  • IRE1,
  • IRE1a,
  • ER to nucleus signalling 1
  • identifiers:
  • 2081,
  • ENSG00000178607,
  • ERN1

Genome feature

Region: gene ? Length: 93328  
Location: 17:64039142-64132469 reverse strand Cyto location: 17q23.3

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650 SN Ps

5 Cross References

18 Data Sets

6 Homologues

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97 Rna Seq Results