help  | about  | cite  | software

Gene : ERN1 Homo sapiens

Name  ? endoplasmic reticulum to nucleus signaling 1 Cytological Location  17q23.3
Brief Description  endoplasmic reticulum to nucleus signaling 1
Description  This gene encodes the transmembrane protein kinase inositol-requiring enzyme 1. The encoded protein contains two functional catalytic domains, a serine/threonine-protein kinase domain and an endoribonuclease domain. This protein functions as a sensor of unfolded proteins in the endoplasmic reticulum (ER) and triggers an intracellular signaling pathway termed the unfolded protein response (UPR). The UPR is an ER stress response that is conserved from yeast to mammals and activates genes involved in degrading misfolded proteins, regulating protein synthesis and activating molecular chaperones. This protein specifically mediates the splicing and activation of the stress response transcription factor X-box binding protein 1. [provided by RefSeq, Aug 2017]
  • synonyms:
  • hIRE1p,
  • IRE1,
  • Serine/threonine-protein kinase/endoribonuclease IRE1,
  • IRE1P,
  • NM_001433,
  • ERN1,
  • uc002jdz.3,
  • OTTHUMG00000178879,
  • IRE1P,
  • HGNC:3449,
  • inositol-requiring enzyme 1,
  • AF059198,
  • IRE1,
  • IRE1a,
  • ER to nucleus signalling 1
  • identifiers:
  • 2081,
  • ENSG00000178607,
  • ERN1

Genome feature

Region: gene ? Length: 93328  
Location: 17:64039142-64132469 reverse strand Cyto location: 17q23.3


Uni Prot Comments Displayer

Protein Atlas Displayer

Gene Expression Atlas Tissues Displayer

Gene Expression Atlas Diseases Displayer

Publication Counts Displayer

Curated Proteins Displayer

Function

Gene Ontology Displayer

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Genomics

J Browse Displayer

Gene Structure Displayer

Overlapping Features Displayer

Mouse Alleles Displayer

Gene --> Chromosomal location.

Gene --> GO terms.

Gene --> Overlapping genes.

Proteins

Gene --> Proteins.

SNPs

Gene Report --> GWAS hit

Disease

0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Homology

Homologue Displayer

Interactions

Cytoscape Network Displayer

Gene --> Physical and Genetic Interactions

Expression

Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.

 

Other

650 SN Ps

5 Cross References

18 Data Sets

6 Homologues

0 Located Features

97 Rna Seq Results