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Gene : F2 Homo sapiens

Name  ? coagulation factor II, thrombin Cytological Location  11p11.2
Brief Description  coagulation factor II, thrombin
Description  This gene encodes the prothrombin protein (also known as coagulation factor II). This protein is proteolytically cleaved in multiple steps to form the activated serine protease thrombin. The activated thrombin enzyme plays an important role in thrombosis and hemostasis by converting fibrinogen to fibrin during blood clot formation, by stimulating platelet aggregation, and by activating additional coagulation factors. Thrombin also plays a role in cell proliferation, tissue repair, and angiogenesis as well as maintaining vascular integrity during development and postnatal life. Peptides derived from the C-terminus of this protein have antimicrobial activity against E. coli and P. aeruginosa. Mutations in this gene lead to various forms of thrombosis and dysprothrombinemia. Rapid increases in cytokine levels following coronavirus infections can dysregulate the coagulation cascade and produce thrombosis, compromised blood supply, and organ failure. [provided by RefSeq, May 2020]
  • synonyms:
  • THPH1,
  • F2,
  • RPRGL2,
  • NM_000506,
  • OTTHUMG00000150344,
  • M33031,
  • prepro-coagulation factor II,
  • HGNC:3535,
  • coagulation factor II (thrombin),
  • PT,
  • uc001ndf.5
  • identifiers:
  • 2147,
  • ENSG00000180210,
  • F2

Genome feature

Region: gene ? Length: 20294  
Location: 11:46719213-46739506 Cyto location: 11p11.2


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Proteins

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SNPs

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Disease

4 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

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3740 SNPs

5 Cross References

19 Data Sets

3 Homologues

0 Located Features

97 Rna Seq Results