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Gene : F2 Homo sapiens

Name  ? coagulation factor II, thrombin Cytological Location  11p11.2
Brief Description  coagulation factor II, thrombin
Description  Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Peptides derived from the C-terminus of this protein have antimicrobial activity against E. coli and P. aeruginosa. Mutations in F2 lead to various forms of thrombosis and dysprothrombinemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]
  • synonyms:
  • F2,
  • RPRGL2,
  • NM_000506,
  • uc001ndf.5,
  • M33031,
  • coagulation factor II (thrombin),
  • PT,
  • THPH1,
  • HGNC:3535,
  • OTTHUMG00000150344,
  • prepro-coagulation factor II
  • identifiers:
  • 2147,
  • ENSG00000180210,
  • F2

Genome feature

Region: gene ? Length: 20306  
Location: 11:46719201-46739506 Cyto location: 11p11.2


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Disease

4 Diseases

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3753 SN Ps

5 Cross References

20 Data Sets

3 Homologues

0 Located Features

97 Rna Seq Results