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Gene : F10 Homo sapiens

Name  ? coagulation factor X Cytological Location  13q34
Brief Description  coagulation factor X
Description  This gene encodes the vitamin K-dependent coagulation factor X of the blood coagulation cascade. This factor undergoes multiple processing steps before its preproprotein is converted to a mature two-chain form by the excision of the tripeptide RKR. Two chains of the factor are held together by 1 or more disulfide bonds; the light chain contains 2 EGF-like domains, while the heavy chain contains the catalytic domain which is structurally homologous to those of the other hemostatic serine proteases. The mature factor is activated by the cleavage of the activation peptide by factor IXa (in the intrisic pathway), or by factor VIIa (in the extrinsic pathway). The activated factor then converts prothrombin to thrombin in the presence of factor Va, Ca+2, and phospholipid during blood clotting. Mutations of this gene result in factor X deficiency, a hemorrhagic condition of variable severity. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing to generate mature polypeptides. [provided by RefSeq, Aug 2015]
  • synonyms:
  • FXA,
  • NM_000504,
  • uc001vsx.4,
  • OTTHUMG00000017374,
  • HGNC:3528,
  • FX,
  • F10
  • identifiers:
  • 2159,
  • ENSG00000126218,
  • F10

Genome feature

Region: gene ? Length: 26731  
Location: 13:113122799-113149529 Cyto location: 13q34


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Disease

1 Diseases

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3753 SN Ps

5 Cross References

19 Data Sets

7 Homologues

0 Located Features

97 Rna Seq Results