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Gene : F13A1 Homo sapiens

Name  ? coagulation factor XIII A chain Cytological Location  6p25.1
Brief Description  coagulation factor XIII A chain
Description  This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion. [provided by RefSeq, Jul 2008]
  • synonyms:
  • F13A,
  • M14539,
  • OTTHUMG00000014186,
  • NM_000129,
  • HGNC:3531,
  • F13A1,
  • uc003mwv.4,
  • F13A,
  • coagulation factor XIII, A1 polypeptide
  • identifiers:
  • 2162,
  • ENSG00000124491,
  • F13A1

Genome feature

Region: gene ? Length: 176579  
Location: 6:6144084-6320662 reverse strand Cyto location: 6p25.1


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Disease

3 Diseases

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122 SN Ps

5 Cross References

19 Data Sets

5 Homologues

0 Located Features

97 Rna Seq Results