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Gene : BPTF Homo sapiens

Name  ? bromodomain PHD finger transcription factor Cytological Location  17q24.2
Brief Description  bromodomain PHD finger transcription factor
Description  This gene was identified by the reactivity of its encoded protein to a monoclonal antibody prepared against brain homogenates from patients with Alzheimer's disease. Analysis of the original protein (fetal Alz-50 reactive clone 1, or FAC1), identified as an 810 aa protein containing a DNA-binding domain and a zinc finger motif, suggested it might play a role in the regulation of transcription. High levels of FAC1 were detected in fetal brain and in patients with neurodegenerative diseases. The protein encoded by this gene is actually much larger than originally thought, and it also contains a C-terminal bromodomain characteristic of proteins that regulate transcription during proliferation. The encoded protein is highly similar to the largest subunit of the Drosophila NURF (nucleosome remodeling factor) complex. In Drosophila, the NURF complex, which catalyzes nucleosome sliding on DNA and interacts with sequence-specific transcription factors, is necessary for the chromatin remodeling required for transcription. Two alternative transcripts encoding different isoforms have been described completely. [provided by RefSeq, Jul 2008]
  • synonyms:
  • FALZ,
  • uc002jgf.4,
  • FAC1,
  • fetal Alzheimer antigen,
  • HGNC:3581,
  • BPTF,
  • NURF301,
  • NURF301,
  • NM_004459,
  • AY282495,
  • OTTHUMG00000132254,
  • NEDDFL,
  • FAC1,
  • NM_182641,
  • FALZ
  • identifiers:
  • 2186,
  • ENSG00000171634,
  • BPTF

Genome feature

Region: gene ? Length: 158876  
Location: 17:67825503-67984378 Cyto location: 17q24.2


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1 Diseases

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0 Pathways

3756 SN Ps

5 Cross References

19 Data Sets

5 Homologues

0 Located Features

97 Rna Seq Results