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Gene : FEN1 Homo sapiens

Name  ? flap structure-specific endonuclease 1 Cytological Location  11q12.2
Brief Description  flap structure-specific endonuclease 1
Description  The protein encoded by this gene removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate, thus passing the substrate from one enzyme to another. The protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication. DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5' end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene. Therefore, secondary structure can deter the protective function of this protein, leading to site-specific trinucleotide expansions. [provided by RefSeq, Jul 2008]
  • synonyms:
  • DNase IV,
  • L37374,
  • NM_004111,
  • MF1,
  • FEN1,
  • uc001nsg.4,
  • OTTHUMG00000168162,
  • HGNC:3650,
  • FEN-1,
  • RAD2,
  • maturation factor-1,
  • RAD2,
  • MF1,
  • FEN-1
  • identifiers:
  • 2237,
  • ENSG00000168496,
  • FEN1

Genome feature

Region: gene ? Length: 4328  
Location: 11:61792911-61797238 Cyto location: 11q12.2

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0 Diseases

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156 SN Ps

5 Cross References

16 Data Sets

8 Homologues

2 Located Features

97 Rna Seq Results