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Gene : FGB Homo sapiens

Name  ? fibrinogen beta chain Cytological Location  4q31.3
Brief Description  fibrinogen beta chain
Description  The protein encoded by this gene is the beta component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including afibrinogenemia, dysfibrinogenemia, hypodysfibrinogenemia and thrombotic tendency. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014]
  • synonyms:
  • OTTHUMG00000150331,
  • NM_005141,
  • uc003ioa.5,
  • fibrinogen, B beta polypeptide,
  • HEL-S-78p,
  • FGB,
  • HGNC:3662
  • identifiers:
  • 2244,
  • ENSG00000171564,
  • FGB

Genome feature

Region: gene ? Length: 9828  
Location: 4:154562980-154572807 Cyto location: 4q31.3


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Proteins

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SNPs

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Disease

2 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

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Gene -> HPO annotation (Human Phenotype Ontology)

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Expression

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Other

76 SN Ps

5 Cross References

20 Data Sets

6 Homologues

0 Located Features

97 Rna Seq Results