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Gene : FHIT Homo sapiens

Name  ? fragile histidine triad diadenosine triphosphatase Cytological Location  3p14.2
Brief Description  fragile histidine triad diadenosine triphosphatase
Description  The protein encoded by this gene is a P1-P3-bis(5'-adenosyl) triphosphate hydrolase involved in purine metabolism. This gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. The encoded protein is also a tumor suppressor, as loss of its activity results in replication stress and DNA damage. [provided by RefSeq, Aug 2017]
  • synonyms:
  • NM_002012,
  • fragile histidine triad,
  • uc003dkx.5,
  • FRA3B,
  • HGNC:3701,
  • fragile histidine triad gene,
  • AP3Aase,
  • FRA3B,
  • bis(5'-adenosyl)-triphosphatase,
  • OTTHUMG00000158591,
  • AP3Aase,
  • BC032336,
  • FHIT
  • identifiers:
  • 2272,
  • ENSG00000189283,
  • FHIT

Genome feature

Region: gene ? Length: 1504185  
Location: 3:59747277-61251461 reverse strand Cyto location: 3p14.2


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Function

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Gene -> HPO annotation (Human Phenotype Ontology)

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Genomics

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Proteins

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SNPs

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Disease

0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

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Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

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Expression

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Other

658 SN Ps

5 Cross References

18 Data Sets

3 Homologues

0 Located Features

97 Rna Seq Results