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Gene : ADGRL1 Homo sapiens

Name  ? adhesion G protein-coupled receptor L1 Cytological Location  19p13.12
Brief Description  adhesion G protein-coupled receptor L1
Description  This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. Latrophilin-1 has been shown to recruit the neurotoxin from black widow spider venom, alpha-latrotoxin, to the synapse plasma membrane. Alternative splicing results in multiple variants encoding distinct isoforms.[provided by RefSeq, Oct 2008]
  • synonyms:
  • KIAA0821,
  • LPHN1,
  • OTTHUMG00000182138,
  • CIRL1,
  • LEC2,
  • NM_014921,
  • latrophilin 1,
  • AB020628,
  • LPHN1,
  • HGNC:20973,
  • ADGRL1,
  • CIRL1,
  • LEC2,
  • CL1
  • identifiers:
  • 22859,
  • ENSG00000072071,
  • ADGRL1

Genome feature

Region: gene ? Length: 58509  
Location: 19:14147737-14206245 reverse strand Cyto location: 19p13.12

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0 Diseases

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0 Pathways

427 SN Ps

5 Cross References

16 Data Sets

5 Homologues

0 Located Features

97 Rna Seq Results